ISSN 2094-2818

Editors: Eduardo A. Padlan and
Gisela P. Padilla-Concepcion
VOLUME 7 NUMBER 1 (January to June 2014)

Phil. Sci. Lett. 2014 7 (1) 207-227
available online: May 31, 2014

*Corresponding author
Email Address:
Received: September 26, 2013
Revised: February 10, 2014
Accepted: February 19, 2014
Published: May 31, 2014
Editor-in-charge: Fabian M. Dayrit
Reviewers: Fabian M. Dayrit, Tatsufumi Okino,
Nina Rosario L. Rojas, and Rosalia C. M. Simmen

Keywords: Philippine marine biodiversity, cancer, anticancer compounds, marine natural products, cell cycle, DNA, cancer molecular targets, drug discovery

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Anticancer compounds from Philippine marine organisms act on major pathways in cancer

by Gisela P. Concepcion1, Andrea Roxanne J. Anas1,2, and Miguel A. Azcuna1*

1The Marine Science Institute, University of the Philippines, Diliman, Quezon City 1101, Philippines
2Graduate School of Environmental and Human Science and Faculty of Pharmacy, Meijo University, Tempaku,
  Nagoya 468-8503, Japan

Philippine marine biodiversity ranks among the richest in the world and is still largely unexplored. Such biodiversity can have profound applications in the search for compounds with anticancer properties. Our increased understanding of the molecular mechanisms in cancer has enabled us to demonstrate exactly how these compounds work. In the past two decades, compounds with diverse structures from Philippine marine organisms, ascidians, and associated microorganisms were reported. These compounds are cytotoxic to a variety of cancer cell lines and act on specific molecular targets in major cell signaling pathways implicated in cancer. To address the challenges associated with developing marine natural products for the pharmaceutical drug pipeline, future directions will focus on optimizing the culture of marine organisms and symbionts, utilizing biosynthetic genes in microbial hosts, and developing the concept of treating cancer with combinatorial therapy.